NATURDAO - 1,000,000 HDU - DAO Enzyme Supplement - Histamine Block - Diamine Oxidase - Food Intolerance - 60 Tablets

Thanks to this supplement, I can eat whatever I want now. Previously I was on a low histamine diet, only eating certain foods & using a pork based DAO (blech). Then I decided to make the swap to this vegan version because it's so much stronger with the 1,000,000 HDU & only needs 5 minutes to start working! It took about a week or two for me to stabilize my histamine levels with this enzyme. And now? This weekend I ate hibachi, miso soup, pizza, pickles & ranch. No problem. Never have experienced any side effects, either. Highly, highly recommend if you're dealing with histamine intolerance. Seriously a game changer!

I have a form of histamine intolerance in which there are genetic mutations in my DAO and HNMT enzymes, leading to a slower clearance of histamine and allergic reactions upon ingestion of histamine rich foods. Taking one of these shortly before a meal eliminates most of the symptoms. I avoid the worst offenders (ex sauerkraut, cured meats) but other than that I am now able to eat freely with, at worst, mild easily tolerable symptoms.I experimented with higher doses, going up to 3 per meal (6 per day). While my histamine symptoms went from mild to zero, my depression significantly worsened, and I had a constant mild stomach ache. As another review mentioned, this pea DAO enzyme may break down precursors to neurotransmitters like serotonin and dopamine at higher doses, which could worsen depression. Upon lowering the dose back to 1-2 per day, the side effects went away within a few days.Overall, it's a great help for my histamine intolerance, just watch out for worsening of depression.

Expensive but very good quality DAO supplementHighly recommend this brand, just one tablet will mostly reverse a bad histamine reaction in an hour which is life-saving for me! No prescription needed.

I’m sure this works for some people but it’s definitely not for me. My allergist wanted me to try it to help lower my histamine level since it breaks down histamine in food. I took one pill one time and I will never take it again. It gave me the worst stomach cramps, bloating, gas, and nausea that I’ve had in a long time. No amount of stomach meds could touch it. I took it at supper and felt sick the rest of the night and the next morning. Unfortunately you can’t return the item so I’m out almost $40 for one pill. I’m very sensitive to things so like I said it may work for others but if you’re sensitive like me, beware.

I've had rosacea for about six years. I've tried all kinds of creams, supplements, laser treatments, diet changes; nothing stopped the hot, painful facial flushing. After doing a ton more research and tracking my symptoms, I came to the conclusion that my rosacea is either caused or heavily influenced by a histamine intolerance or possible MCAS (which I suspect is caused by SIBO, but that's a whole nother beast). I was starting to flush after nearly every single meal, it was getting unbearable.I started experimenting, adding in several antihistamines a day along with this supplement. I slowly worked my way up to 1 entire pill since I was a bit scared of a bad reaction after reading some of the negative reviews. Luckily my body adapted fine. The first few times I took it, my chronically stuffy sinuses unclogged within literal minutes, it was weird but awesome (sadly didn't last!).More importantly, this supplement has made a HUGE decrease in my food-induced flare ups. Along with my regimen of antihistamines (h1 and h2 blockers) my after-meal flushing has become basically nonexistent, the change is almost unbelievable. Because I'm flushing less from meals, it means I'm flushing less all day long since my skin is staying calmer overall. Unfortunately it doesn't work on alcohol, I definitely still flush from that, but I had to test it lol.That leads me to the only drawback: the price. I've already gone through several boxes of these and it's only been a few months. I'm fortunate that I only need one pill for each meal and that I only eat twice a day, but man, I can't imagine if you needed several pills per meal and ate three full meals a day. And these are one of the cheapest DAO supplements on the market! Yikes. It's not sustainable, at least not for me, especially since I have a pretty large regimen of other supplements I need to pay for.I've considered 1. switching to eating one meal a day to save on costs, 2. going a strict anti-histamine diet to see if that decreases my need for the supplement, 3. growing my own pea sprouts (apparently they're high in DAO; who knew) 4. and/or cutting the pills in half to make them stretch further (you'll most likely need a pill cutter if you do this, these are HARD to cut with a knife).I even tried skipping them and just using my antihistamines only before meals to see if I could do without them but sadly, that didn't prevent a flush. As soon as I felt the flush coming on I quickly took one and my skin calmed down within minutes, so I know these are having a big impact all on their own.For now I plan to keep taking them despite my crying wallet, but I'm hoping I can get to the root cause of my histamine intolerance so that some day I no longer need them.